What is Lymphedema?

Lymphedema is abnormal accrual of protein rich fluid in the space between the cells that are outside of the blood vessels. This high protein content results in fibrosis, or the hardening of the fluid and surrounding tissue and can lead to changes in the skin, including hyperkeratosis and papillomas. Lymphedema can be either primary (arising from a genetic defect, i.e., inherited lymphedema) or secondary (arising from an injury to the lymphatic system). Primary lymphedema is more commonly noticed to be equal between sides, while secondary is typically worse unilaterally. Lymphedema is a chronic disease for which currently there is no known cure, though treatment is available.